International


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Title: Impact of JAK-STAT inhibition on the metabolic syndrome and cardiovascular risk associated with rheumatoid arthritis
Principal investigator: Nuria Barbarroja y Alejandro Escudero Contreras
Research team: Eduardo Collantes, Rosario López, Iván Arias, Rafaela Ortega, Jerusalem Calvo, M Carmen Castro, Alejandra Patiño, María Luque
Funding entity: ISR Aspier Pfizer
Start-End date: 01-01-2020/31-12-2021
Total amount: 50.000 €


Title: Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions. 3TR
Principal investigator: Marta Alarcon Riquelmey Eduardo Collantes Estévez
Research team: Rosario López Pedrera, Alejandro Escudero Contreras, Rafaela Ortega Castro, Nuria Barbarroja Castro, Lourdes Ladehesa Pineda, M Ángeles Aguirre Zamorano, M Carmen Castro Villegas, Iván Arias de la Rosa, Alejandra M Patiño Trives, María Luque Tevar, Jerusalem Calvo Gutierrez, Clementina López Medina, M Carmen Ábalos Aguilera, Carmen Torres Granados, Ignacio Gómez García, Marta Rojas Giménez, Pedro Armenteros Ortiz
Funding entity: IMI 2, Innovative Medicine Initiative 2
Start-End date: 01/09/2019 - 31/08/2026
Total amount: 80.803.178 €


Title: Molecular reclassification to find clinically useful biomarkers for systemic autoinmune diseases (PRECISESADS)
Principal investigator: Marta Alarcon Riquelme y Eduardo Collantes Estévez
Research team: Rosario López Pedrera, M Ángeles Aguirre Zamorano, Rafaela Ortega Castro, Nuria Barbarroja Puerto, Yolanda Jiménez Gómez, Carlos Pérez Sánchez, Patricia Ruiz Limón, M Carmen Ábalos Aguilera
Funding entity: IMI, Innovative, Medicines Initiative (European Union) 
Start-End date: 20/02/2014 - 20/02/2019 
Total amount: 9.988.693,98 €


Title: Can Inertial Movement Sensors (IMUs) provide a valid and reliable way of measuring Spinal Mobility in Axial Spondyloarthritis (axSpa): a Clinimetric Evaluation
Principal investigator: Philip Gardiner y Eduardo Collantes Estévez
Research team: Eduardo Collantes Estévez, Juan Luis Garrido
Funding entity: Foundation for Research in Rheumatology (FOREUM)
Start-End date: 01/05/2016 - 31/05/2019
Total amount: 270.000 €


National

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Title: Involvement of the intestinal microbiota in radiographic progression in patients with axial spondyloarthritis
Principal investigator: Eduardo Collantes Estévez
Research team: Jerusalem Calvo Gutierrez, Rafaela Ortega Castro, Juan Luis Garrido, Clementina López Medina, Ignacio Gómez García, María del Carmen Ábalos Aguilera, Patricia Ruiz Limón, Rocío Segura Ruiz
Funding entity: Fund for Health Research of the Ministry of Health Carlos III, (DTS19/00701)
Start-End date: 01/01/2020 - 31/12/2022
Total amount: 87.120 €


Title: Development and validation of the use of inertial sensors applied to the metrology of patients with Axial Spondyloarthritis
Principal investigator: Eduardo Collantes Estévez
Research team: Antonio Cuesta Vargas, Luis Jiménez Reina, Manuel Arias López, Pilar Font Ugalde, Verónica Pérez Guijo, María del Carmen Castro Villegas, Rafael Raya López, Juan Luis Garrido Castro, Francisco Alburquerque Sendin, Jerusalem Calvo Gutierrez, Luis Manuel Fernández de Ahumaa
Funding entity: Fund for Health Research of the Ministry of Health Carlos III, (DTS18/00046)
Start-End date: 01/01/2019 - 31/12/2020
Total amount: 31.350 €


Title: Identification of molecular heterogeneity associated with cardiovascular disease, clinical evolution and therapeutic response in patients with autoimmune diseases
Principal investigator: Rosario López Pedrera
Research team: M Ángeles Aguirre Zamorano, M José Cuadrado Lozano, Pilar Font Ugalde, M Carmen Castro Villegas, Mario Espinosa Hernández, Carlos Pérez Sánchez, Patricia Ruiz Limón, Alejandro Ibáñez Costa, Rafaela Ortega Castro, Savino Sciascia, Iván Arias de la Rosa, Massimo Radin, Irene Cecchi
Funding entity: Fund for Health Research of the Ministry of Health Carlos III, (PI18/00837)
Start-End date: 01/01/2019 - 31/12/2021
Total amount: 141.570 €


Title: Study of the epigenetic mechanisms involved in the development of insulin resistance and obesity associated with rheumatoid arthritis and psoriatic arthritis.
Principal investigator: Nuria Barbarroja y Alejandro Escudero
Research team: Carlos Pérez Sánchez, Pilar Font Ugalde, M Dolores López Montilla, Irene Cecchi, Sergio Rodríguez Cuenca, Savino Sciascia, Massimo Radin
Funding entity: Fund for Health Research of the Ministry of Health Carlos III, (PI17/01316)
Start-End date: 01/01/2018 - 31/12/2020
Total amount: 93.170 €


Title: Study of the mechanisms of atherothrombosis in systemic autoimmune diseases by integration of inmunological, molecular and epigenetic analysis. New therapies
Principal investigator: Chary Lopez-Pedrera
Research team: M Ángeles Aguirre Zamorano, M José Cuadrado Lozano, Pilar Font Ugalde, M Carmen Castro Villegas, Yolanda Jiménez Gómez, Carlos Pérez Sánchez, Nuria Barbarroja Puerto, Rafaela Ortega Castro, Savino Sciascia
Funding entity: Fund for Health Research of the Ministry of Health Carlos III, (PI15/01333)
Start-End date: 01/01/2016 - 31/12/2018
Total amount: 110.715 €


Title: Role of the inflamed joints in the development of insulin resistance and atherosclerosis related to rheumatoid arthritis
Principal investigator: Nuria Barbarroja Puerto
Research team: Iván Arias de la Rosa
Funding entity: Fund for Health Research of the Ministry of Health Carlos III (CP15/00158).
Start-End date: 01/01/2016 - 31/12/2018
Total amount: 61500 €


Title: Mechanisms of atherosclerosis and cardiovascular disease in systemic autoimmune disorders. New therapeutic approaches.
Principal investigator: Rosario Lopez Pedrera
Research team: M Ángeles Aguirre Zamorano, M José Cuadrado Lozano, Pilar Font Ugalde, M Carmen Castro Villegas, Munther Khamastha, Carlos Pérez Sánchez, Nuria Barbarroja Puerto, Patricia Ruiz Limón, Rosario Carretero Prieto
Funding entity: Fund for Health Research of the Ministry of Health Carlos III (CP12/01511).
Start-End date: 01/01/2013 - 31/12/2015
Total amount: 116000 €


Title: Early detection of lung, breast, colon and bladder cancer
Principal investigator: Antonio Rodriguez Ariza
Research team: Rosario López Pedrera, Nuria Barbarroja Puerto, Carlos Pérez Sánchez
Funding entity: Ministry of Economy and Competitivity (MINECO)
Start-End date: 01/01/2012 - 31/12/2015
Total amount: 4870000 €


Title: Analysis of the mechanisms involved in the development and control of atherothrombosis in systemic autoimmune diseases. New therapeutic strategies
Principal investigator: Alejandro Escudero Contreras
Funding entity: Spanish Association of Rheumatology
Start-End date: 01/01/2013 - 31/12/2013
Total amount: 22000 €


Title: Follow up of the therapeutic response in patients with ankylosing spondylitis through a new metrological index based on the analysis of the movement
Principal investigator: Eduardo Collantes Estevez
Funding entity: Fund for Health Research of the Ministry of Health Carlos III (10/01524)
Start-End date: 10/12/2010 - 31/12/2013
Total amount: 57.475 €


Title: Analysis of the cellular and molecular mechanisms underlying the mitochondrial dysfunction and oxidative stress in the atherothrombosis en la aterotrombosis related to systemic autoinmune diseases. Genomic and proteomic studies
Principal investigator : Rosario Lopez Pedrera
Funding entity: Fund for Health Research of the Ministry of Health Carlos III
Start-End date: 01/01/2009 - 01/01/2012
Total amount: 103.000 €


Title: Study of the mitochondrial dysfunction and oxidative stress in the atherothrombosis related to rheumatoid arthritis. Genomic and proteomic study
Principal investigator: Maria Angeles Aguirre
Funding entity: Spanish Association of Rheumatology
Start-End date: 01/01/2009 - 01/01/2011
Total amount: 44.000 €


Title: Cellular and molecular mechanisms in response to the treatment with new antitumoral drugs in the Acute Myeloid Leukemia: Effect in the angiogenesis and tumoral progression. Proteomic study
Principal investigator: Rosario Lopez Pedrera
Funding entity: Fund for Health Research of the Ministry of Health Carlos III (PI050910)
Start-End date: 01/01/2006 - 01/01/2009
Total amount: 135.660 €


Regional
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Title: Cellular and molecular mechanisms involved in the atherothrombosis related to systemic autoinmune diseases: epigenetic study and analysis of the effects of new therapeutic strategies.
Principal Investigator: Rosario López Pedrera
Funding entity: Incentives fund to research excellence projects. Regional ministry of Innovation, Science and technology, Andalusian Regional Government
Start-End date: 01/01/2012 - 01/01/2016
Total amount: 262.922 €


Title: Role of the inflamed joints in the development of insulin resistance and atherosclerosis related to rheumatoid arthritis
Principal Investigator: Nuria Barbarroja Puerto
Funding entity: Regional Ministry of Health, Andalusian Regional Government
Start-End date: 01/01/2014 - 31/12/2016
Total amount: 52.500 €


Title: Study of new molecular targets involved in the inflammation and the alteration of fibrosous tissue and bone in the ankylosing spondylitis. Therapeutic alternatives.
Principal investigator: Alejandro Escudero Contreras
Funding entity: Regional Ministry of Health, Andalusian Regional Government
Start-End date: 01/12/2013 - 31/12/2015
Total amount: 52.500 €


Title: Biomechanical analysis of the movement and balance for the evaluation of the efficacy of the intrajoint treatments in patients with knee osteoarthritis
Principal Investigator: Veronica Pérez Guijo
Funding entity: Regional Ministry of Health, Andalusian Regional Government (PI-0049-2011)
Start-End date: 17/05/2012 - 17/05/2015
Total amount: 44.202 €


Title: Use of an analysis system of movement for the evaluation of the efficacy of the biologic therapies in the patients with ankylosing spondylitis.
Principal Investigator: Eduardo Collantes Estevez
Funding entity: Regional Ministry of Equality, Health and Social policy
Start-End date: 01/01/2010 - 31/12/2013
Total amount: 41.639 €


Title: Analysis of the molecular and cellular mechanisms modulators of the effect of fluvastatin and new antioxidant drugs in the prevention of the thrombosis and atherothrombosis related to the antiphospholipid syndrome and systemic lupus erythematosus. Genomic and proteomic study
Principal Investigator: Francisco Velasco Gimena
Funding entity: Incentives fund to research excellence projects. Regional ministry of Innovation, Science and technology, Andalusian Regional Government
Start-End date: 01/01/2009 - 01/01/2013
Total amount: 252.923,98 €


Title: Study of the cellular and molecular mechanisms involved in the response to treatment with new antitumoral drugs and chemotherapeutic in the Acute Myeloid Leukemia in relation to its specific molecular profile. Genomic and proteomic study.
Principal Investigator: Rosario López Pedrera
Funding entity: Regional Ministry of Health, Andalusian Regional Government
Start-End date: 2008 - 2010
Total amount: 56500 €


Title: Analysis of the mitochondrial dysfunction and oxidative stress in the atherothrombosis associated with systemic autoinmune diseases. Genomic and proteomic study.
Principal Investigator: Rosario López Pedrera
Nº of colaborators: 8
Funding entity: Regional Ministry of Health, Andalusian Regional Government (PI-09/0246)
Start-End date: 2010 - 2012
Total amount: 45.900 €


Title: Analysis of the mitochondrial dysfunction and oxidative stress in the atherothrombosis associated with systemic autoinmune diseases.
Principal Investigator: Mª Angeles Aguirre Zamorano
Funding entity: Andalusian Foundation of Rheumatology
Start-End date: 2009 - 2010
Total amount: 22000 €


Title: Analysis of the cellular and molecular mechanisms modulators of the effect of statins and new antioxidant drugs in the prevention of the thrombosis and aterothrombosis associated with antiphospholipid syndrome and systemic lupus erythematosus.
Principal Investigator: Francisco Velasco Gimena
Funding entity: Regional Ministry of Health, Andalusian Regional Government (PI0042/2007)
Start-End date: 2008 - 2010
Total amount: 44000 €


Title: Analysis of the cellular and molecular mechanisms modulators of the effect of statins and new antioxidant drugs in the prevention of the thrombosis and aterothrombosis associated with antiphospholipid syndrome and systemic lupus erythematosus.
Principal Investigator: Mª Angeles Aguirre Zamorano
Funding entity: Andalusian Foundation of Rheumatology
Start-End date: 2008 - 2009
Total amount: 22000 €


Company Agreements

 

08biohopecanaan

 

Title: Identification and caracterization of new biomarkers  as predictors of response to biological therapies in Rheumatoid Arthritis. 
Principal Investigator: Chary López Pedrera
Funding entity: Roche Pharma, S.A
Start-End date: 2019-2020
Total amount: 17.000 €


Title: Pilot study to evaluate the feasibility and analytical robustness of a new pharmacological test of immunosuppressive drug sensitivity / resistance designed to personalize the medical treatment of Rheumatoid Arthritis (Immunobiogram ®)
Principal Investigator: Alejandro Escudero Contreras
Funding entity: Biohope Scientific Solutions for Human Health, SL
Start-End date: 2018-2019
Total amount: 45000 €


Title: Effect of arthritis on liver function and modulation by FAMEs. Murine model of arthritis and in vitro studies
Principal Investigator: Nuria Barbarroja Puerto
Funding entity: Roche Pharma, S.A
Start-End date: 2018-2019
Total amount: 25000 €


Title: Development of a biomarker of Rheumatoid Arthritis
Principal Investigator: Rosario López Pedrera
Funding entity: Cannan Reserach Investment S.L.
Start-End date: 2017-2018
Total amount: 10000 €


Title: Effect of methotrexate, leflunomide and hidroxichloroquine in the metabolic syndrome and obesity associated with rheumatoid arthritis: arthritis mouse model
Principal Investigator: Nuria Barbarroja Puerto
Funding entity: Roche Pharma, S.A
Start-End date: 01/01/2017 - 31/12/2017
Total amount: 25000 €


Title: Role of the inflamed joints in the development of insulin resistance and atherosclerosis associated with the rheumatoid arthritis
Principal Investigator: Eduardo Collantes Estevez
Funding entity: Roche Pharma, S.A
Start-End date: 01/01/2016 - 31/12/2016
Total amount: 25000 €


Title: Evaluation of the IL6 levels in patients with active rheumatoid arthritis. Correlation with the therapeutic response to biologic therapies and benefit in the mitochondrial function and the oxidative stress associated with the development of atherothrombosis: comparative analysis of anti-TNFa drugs and tocilizumab.
Principal Investigator: Eduardo Collantes Estevez
Funding entity: Roche Pharma, S.A
Start-End date: 01/01/2015 - 31/12/2015
Total amount: 25000 €