The human side of animal experimentation: A qualitative, exploratory study into work-related stress and coping in animal experimenters

Main Article Content

Lisa Maria Glenk
Cornelia Belik
Rupert Palme
Andreas Aigner
Erika Jensen-Jarolim

Abstract

Besides the pervasive controversy of animal experimentation in society, ethics and science, the human experimenter side of laboratory animal studies is a relatively underrepresented topic in human-animal interaction research. Few studies have addressed scientists’ stress responses to animal experiments. The main aim of this study was to assess work-related stress by means of salivary cortisol secretion, coping strategies, self-esteem, pet attitude and personality traits in academic researchers who regularly perform invasive animal experiments. Invitation to participate in the study resulted in a response rate of 15.4% of 65 invited scientists, of which only four (6.15%) completed data collection. Study participants carried out saliva sampling on working days with and without animal experiments, completed a semi-structured qualitative interview and psychological questionnaires. Salivary cortisol (SC) was measured via enzyme immunoassay. The results indicate that animal experimenters used problem-focused and emotion-focused coping strategies. Three participants reached above average values in self-esteem. Pet attitudes scores were moderately positive. Three out of four animal experimenters reached high scores on the personality dimensions "openness to experience", "agreeableness" and "conscientiousness". In the absence of an acute increase in SC related to animal experimentation, two out of four participants exhibited an altered circadian pattern of SC secretion only on working days with animal experiments. Although and as a matter of fact because only four of 65 invited scientists volunteered to participate, we discussed the seemingly low willingness of researchers to participate in such a study based on a theoretical analysis, particularly highlighting the concept of deindividuation and provide suggestions for future research.

Article Details

Section
Research papers

References

Arluke, A. B. 1988. Sacrificial Symbolism in Animal Experimentation: Object or Pet?. Anthrozoos, 2(2), 98-117. DOI: 10.2752/089279389787058091.

Ary, D., Jacobs, L. C., Sorensen Irvin, C. K. and Walker, D. A. 2014. Introduction to Research in Education (9. Ed). Wadsworth: Cengage Learning.

Baumans, V. 2005. Science-based assessment of animal welfare: laboratory animals. Revue scientifique et technique de l`Office international des Epizooties, 24, 503-514, from http://web.oie.int/boutique/extrait/baumans503514.pdf.

Binder, R. and Grimm, H. 2013. Was heißt es, Verantwortung zu übernehmen?. In R. Binder, Alzmann, N. and Grimm, H, (Eds.), Wissenschaftliche Verantwortung im Tierversuch: Ein Handbuch für die Praxis (pp. 9-22). Baden-Baden: Nomos.

Binder, R., Alzmann, N. and Grimm, H. 2013. Wissenschaftliche Verantwortung im Tierversuch: Ein Handbuch für die Praxis. Baden-Baden: Nomos.

Breckler, S., Olson, J. and Wiggins, E. 2005. Conformity, Compliance, and Obedience. In S. Breckler, J. Olson and Wiggins, E. (Eds.), Social Psychology Alive (pp. 305-342). Belmont: Thomson Learning Inc.

Brom, C., Buchtová, M., Sisler, V., Dêchtêrenko, F., Palme, R. and Glenk, L. M. 2014. Flow, social-interaction anxiety and salivary cortisol responses in serious games: A quasi-experimental study. Computers and Education, 79, 69–100. DOI: 10.1016/j.compedu.2014.07.001.

Ehinger, B. E. 1986. Animal experimentation ethics from an experimenter's point of view. Acta physiologica Scandinavica. Supplementum, 554, 69-77. from https://www.ncbi.nlm.nih.gov/pubmed/3469887.

Gärtner, K. 1991. Sonderforschungsbereich Versuchstierforschung: Qualitäts-kriterien der Versuchstierforschung (Ergebnisse aus dem Sonderforschungs-bereich „Versuchstierforschung" der Medizinischen und der Tierärztlichen Hochschule Hannover). Weinheim: Wiley-VCH.

Glenk, L. M. and Kothgassner, O. D. 2017. Life Out of Balance: Stress-Related Disorders in Animals and Humans. In E. Jensen-Jarolim (Ed.), Comparative Medicine: Disorders Linking Humans with Their Animals (pp. 97-107). Basel: Springer International Publishing.

Grimm, H. and Binder, R. 2013. Ethik im Kontext des Tierversuchs. In R. Binder, Alzmann, N. and Grimm, H, (Eds.), Wissenschaftliche Verantwortung im Tierversuch: Ein Handbuch für die Praxis (pp. 23-54). Baden-Baden: Nomos.

Kang, M., Han, A., Kim, D., Seidle, T., Lim, K-M and Bae, S. 2018. Mental Stress from Animal Experiments: a Survey with Korean Researchers. Toxicol Research, 34 (1), 75-81, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776918/.

Lazarus, R. S. and Folkman, S. 1984. Stress, Appraisal and Coping. New York: Springer.

Lovallo, W. R., Farag, N. H., Vincent, A. S., Thomas, T. L. and Wilson, M. F. 2006. Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacology Biochemistry and Behavior, 83, 441-447. DOI: 10.1016/j.pbb.2006.03.005.

Lupien, S. J., Fiocco, A., Wan, N., Maheu, F., Lord, C., Schramek, T. and Thanh Tu, M. 2005. Stress hormones and human memory function across the lifespan. Psychoneuroendocrinology , 30, 225–242. DOI: 10.1016/j.psyneuen.2004.08.003.

Maina, G., Bovenzi, M., Palmas, A., Rossi, F. and Filon, F. L. 2012. Psychosocial environment and health: Methodological variability of the salivary cortisol measurements. Toxicology Letters, 213, 21– 26. DOI: 10.1016/j.toxlet.2011.08.019.

Monamy, V. 2009. Animal experimentation: a guide to the issues (2. Ed.). Cambridge: Cambridge Univ. Press.
Ormandy, E. H. and Schuppli, C. A. 2014. Public Attitudes toward Animal Research: A Review. Animals, 4, 391-408, from https://www.ncbi.nlm.nih.gov/pubmed/26480314.

Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D. J., Lightman, S., Vgontzas, A. and Van Cauter, E. 2016. The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids. Endocrine reviews, 38(1), 3-45. DOI: 10.1210/er.2015-1080.

Palme, R., Möstl, E. 1997. Measurement of cortisol metabolites in faeces of sheep as a parameter of cortisol concentration in blood. Zeitschrift für Säugetierkunde, 62, 192-197, Suppl. 2.

Perry, P. 2007. The ethics of animal research: a UK perspective. ILAR Journal, 48, 42-46. DOI: 10.1093/ilar.48.1.42.

Phillips, C. J. C., Izmirli, S., Aldavood, S. J., Alonso, M., Choe, B. I., Hanlon, A., Handziska, A., Illmann, G., Keeling, L., Kennedy, M., Lee, G. H., Lund, V., Mejdell, C., Pelagic, V. R. and Rehn, T. 2012. Students' attitudes to animal welfare and rights in Europe and Asia. Animal Welfare, 21, 87-100.

Rai, T. S., Valdesolo, P. and Graham, J. 2017. Dehumanization increases instrumental violence, but not moral violence. PNAS, 114(32), 8511-8516. DOI: 10. 1073/pnas.1705238114/-/DCSupplemental.
Rowan, A. N. 1988. Editorial: Companion Animals in the Laboratory. Anthrozoos, 3(2), 73. DOI: 10.2752/089279390787057702.

Scheier, M. F., Weintraub, J. K. and Carver, C. S. 1986. Coping with stress: Divergent strategies of optimists and pessimists. Journal of Personality and Social Psychology, 51, 1257-1264.

Spears, R. and Lea, M. 1994. Panacea or panopticum? The hidden power in computer-mediated communiation. Communication research, 21(4), 427-495. DOI: 10.1177/009365094021004001.

Statistik Austria 2017. Tierversuchsstatistik 2017. Retrieved February 23, 2019, from https://bmbwf.gv.at/fileadmin/user_upload/Tierversuchsstatistik_2017.pdf.

Stone, A. A., Schwartz, J .E., Smyth, J., Kirschbaum, C., Cohen, S., Hellhammer, D. and Grossman, S. 2001. Individual differences in the diurnal cycle of salivary free cortisol: a replication of flattened cycles for some individuals. Psychoneuroendocrinology, 26, 295–306.

von den Driesch, A. and Peters, J. 2003. Geschichte der Tiermedizin: 5000 Jahre Tierheilkunde (2nd ed.). Stuttgart: Schattauer, F.K. Verlag.
Vilanova, F., Beria, F. M., Costa, Â. B. and Koller, S. H. 2017. Deindividuation: From Le Bon to the social identity model of deindividuation effects. Cogent Psychology, 4, 1-21. DOI: 10.1080/23311908.2017.1308104.

Waytz, A. and Epley, N. 2011. Social connection enables dehumanization. Journal of Experimental Social Psychology, 48, 70-76. DOI: 10.1016/j.jesp.2011.07.012.