Systems Biology towards Novel Chronic Kidney Disease Diagnosis and Treatment. (SysKID)
SysKid, a large-scale integrating European research project, aims at deepening our understanding of chronic kidney disease. The project paves the way for progress in prevention, new diagnostic strategies and treatment options for declining kidney function, which affects millions of patients suffering from diabetes and hypertension.
General objectives
Identify persons at risk of developing chronic kidney disease utilizing epidemiology as well as molecular tools.
Understand the molecular processes triggering early stage chronic kidney disease and identify associated biomarkers.
Develop novel diagnostic and therapeutic strategies to control progression of chronic kidney disease.
Perform pre-clinical verification of novel therapy approaches and perform clinical testing of novel diagnostics.
Role of the andalusian partner
i) the identification and functional characterization of target genes to be assessed in in-vivo settings
ii) the identification of interacting partners of selected biomarker candidates and their regulation
iii) the search of novel biomarkers of CKD to predict disease progression
iv) the analysis of the pathophysiological effects of biomarkers and mediators, brought into the consortium or identified in the framework of the project, on the progression of CKD
v) evaluation of novel therapy approaches. Animal models of progressive CKD will be used.