The current COVID-19 pandemic is causing a health crisis of extraordinary importance, with a social and economic impact not previously experienced by several generations. To mitigate the terrible impact of SARS-CoV-2 infection on society, it is essential to develop prevention and treatment strategies that avoid taking such drastic measures as those adopted so far, and alleviate the collapse of the health system in case of possible outbreaks. To this end, it is essential to identify asymptomatic infected individuals, in order to be able to isolate them and break the chain of infections. In this context, rapid and reliable diagnostic techniques are needed to overcome the limitations of current techniques. Children are considered to be silent carriers of the SARS-CoV-2 virus causing this pandemic, but there are no massive diagnostic studies to confirm this. The present project aims to evaluate the dynamics of antibodies in the serum and saliva of paediatric patients admitted in hospitals, as well as the personnel who have cared for them and their respective couples, in order to obtain seroprevalence results that indicate possible exposure to the virus and the immune response to it. A test based on the powerful Luminex technique will be used to determine the presence of IgA, IgM and IgG antibodies in these samples by reacting with five proteins of the virus. These results will give us an idea of the distribution of the virus in an age group considered to be of lower risk, but with a high potential for transmission.
